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It mostly affects the lungs, making it a pulmonary disease. However, extrapulmonary tuberculosis can result from TB spreading to other areas of the body. The bones, brain, lymph nodes, kidneys, and intestines are examples of common places. Rifampicin and isoniazid, the two most effective first-line medications used to treat tuberculosis, are ineffective against multi-drug resistant tuberculosis. This makes treatment more challenging and necessitates the use of second-line medications, which are less effective and more hazardous.

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